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Anti-CASP8AP2 Antibody

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产品名称: Anti-CASP8AP2 Antibody
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简单介绍

Anti-CASP8AP2 Antibody


Anti-CASP8AP2 Antibody  的详细介绍
Name: Anti-CASP8AP2 Antibody
See all CASP8AP2 primary antibodies
Description: Rabbit polyclonal antibody to CASP8AP2
Specificity: The antibody detects endogenous levels of total CASP8AP2 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human caspase 8 associated protein 2
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Cellular Location: Cytoplasm. Nucleus. Nucleus > PML body. Mitochondrion.

Exported from the nucleus to the mitochondria upon FAS activation.
Database Links:
  • Entrez Gene: 9994?Human
  • Omim: 606880?Human
  • SwissProt: Q9UKL3?Human
  • Unigene: 558218?Human
    		•
    Synonyms:
  • AA387232 Antibody
  • C8AP2_HUMAN Antibody
  • CASP 8 associated protein 2 Antibody
  • CASP8 associated protein 2 Antibody
  • CASP8-associated protein 2 Antibody
  • CASP8AP2 Antibody
  • Caspase 8 associated protein 2 Antibody
  • CED 4 Antibody
  • CED4 Antibody
  • D4Ertd659e Antibody
  • FLASH Antibody
  • FLASH homolog Antibody
  • FLASH homolog RIP 25 Antibody
  • FLASH homolog RIP25 Antibody
  • FLICE associated huge Antibody
  • FLICE associated huge protein Antibody
  • FLICE-associated huge protein Antibody
  • FLJ11208 Antibody
  • KIAA1315 Antibody
  • mKIAA1315 Antibody
  • OTTMUSP00000005125 Antibody
  • RIP 25 Antibody
  • RIP25 Antibody
  • RP23-69G24.1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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