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Anti-CASP14 Antibody

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产品名称: Anti-CASP14 Antibody
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Anti-CASP14 Antibody


Anti-CASP14 Antibody  的详细介绍
Name: Anti-CASP14 Antibody
See all CASP14 primary antibodies
Description: Rabbit polyclonal antibody to CASP14
Specificity: The antibody detects endogenous level of total CASP14 antibody.
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant protein of human CASP14.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
Tissue Specificity: Expressed in keratinocytes of ***** skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels (PubMed:11175259). The p17/10 mature form is expressed in epidermis stratum corneum, the p20/p8 intermediate form in epidermis upper granular cells of the stratum granulosum (PubMed:22825846).
Sequence Similarities: Belongs to the peptidase C14A family.
Post-Translational Modification: Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts on the precursor to yield the p17/p10 mature form (PubMed:22825846). Initially, cleavage between Ile-152 and Lys-153 has been proposed to yield the large and small subunits of the active enzyme (PubMed:12200134).
Cellular Location: Cytoplasm. Nucleus.
Database Links:
  • Entrez Gene: 23581 Human
  • Omim: 605848 Human
  • SwissProt: P31944 Human
  • Unigene: 466057 Human
    		•
    Synonyms:
  • Apoptosis related cysteine protease Antibody
  • CASP 14 Antibody
  • CASP-14 Antibody
  • CASP14 Antibody
  • Caspase 14 apoptosis related cysteine protease Antibody
  • Caspase 14 precursor Antibody
  • Caspase-14 Antibody
  • Caspase-14 subunit p10 Antibody
  • Caspase14 Antibody
  • CASPE_HUMAN Antibody
  • MGC119078 Antibody
  • MGC119079 Antibody
  • MICE Antibody
  • Mini ICE Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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