Anti-CASP1 Antibody

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产品名称: Anti-CASP1 Antibody

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Anti-CASP1 Antibody

Anti-CASP1 Antibody 的详细介绍

Overview

Name:	Anti-CASP1 Antibody See all CASP1 primary antibodies
Description:	Rabbit polyclonal antibody to CASP1
Specificity:	The antibody detects endogenous level of total CASP1 protein.
Applications:	E, WB, IHC
Dilutions:	ELISA: 1:1000-1:10000 Western blotting: 1:1000-1:4000 Immunohistochemistry: 1:25-1:100
Reactivity:	Human
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Predicted MW:	45kd
Formulation:	Supplied at 0.8mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Background:

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

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