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Anti-CASK Antibody

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简单介绍

Anti-CASK Antibody


Anti-CASK Antibody  的详细介绍
Name: Anti-CASK Antibody
See all CASK primary antibodies
Description: Rabbit polyclonal antibody to CASK.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human CASK.
Protein Length: 926
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
Tissue Specificity: Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver.
Involvement in Disease: Mental retardation and microcephaly with pontine and cerebellar hypoplasia: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Affected individuals can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia. A milder phenotype consists of mental retardation alone or associated with nystagmus.

FG syndrome 4: FG syndrome (FGS) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
Sequence Similarities: In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Cellular Location: Nucleus. Cytoplasm. Cell membrane.
Database Links:
  • Entrez Gene: 8573?Human
  • Entrez Gene: 12361?Mouse
  • Entrez Gene: 29647?Rat
  • Omim: 300172?Human
  • SwissProt: O14936?Human
  • SwissProt: O70589?Mouse
  • SwissProt: Q62915?Rat
  • Unigene: 495984?Human
  • Unigene: 327591?Mouse
  • Unigene: 474948?Mouse
  • Unigene: 72627?Rat
    		•
    Synonyms:
  • CAGH39 Antibody
  • Caki Antibody
  • Calcium/calmodulin dependent serine protein kinase Antibody
  • Calcium/calmodulin dependent serine protein kinase (MAGUK family) Antibody
  • Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase Antibody
  • Calcium/calmodulin-dependent serine protein kinase Antibody
  • CAMGUK Antibody
  • CAMGUK protein Antibody
  • CAMGUK, drosophila, homolog of Antibody
  • CASK Antibody
  • CMG Antibody
  • CSKP_HUMAN Antibody
  • DXPri1 Antibody
  • DXRib1 Antibody
  • FGS4 Antibody
  • FLJ22219 Antibody
  • FLJ31914 Antibody
  • hCASK Antibody
  • LIN 2 Antibody
  • Lin 2 homolog Antibody
  • LIN2 Antibody
  • Lin2 homolog Antibody
  • MICPCH Antibody
  • MRXSNA Antibody
  • Pals3 Antibody
  • Peripheral plasma membrane protein CASK Antibody
  • Protein lin-2 homolog Antibody
  • TNRC8 Antibody
  • Trinucleotide repeat containing 8 Antibody
  • Vertebtate LIN2 homolog Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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