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Anti-Casein Kinase Iε (P301) Antibody

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产品名称: Anti-Casein Kinase Iε (P301) Antibody
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Anti-Casein Kinase Iε (P301) Antibody


Anti-Casein Kinase Iε (P301) Antibody  的详细介绍
Name: Anti-Casein Kinase Iε (P301) Antibody
See all Casein Kinase Iε primary antibodies
Description: Rabbit polyclonal antibody to Casein Kinase Iε (P301)
Specificity: Casein Kinase Iε (P301) pAb detects endogenous levels of Casein Kinase Iε protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 250-350 of Human Casein Kinase Iε.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 47 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Tissue Specificity: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Post-Translational Modification: Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
Cellular Location: Cytoplasm. Nucleus.
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