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Anti-Casein Kinase Iα (F158) Antibody

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产品名称: Anti-Casein Kinase Iα (F158) Antibody
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Anti-Casein Kinase Iα (F158) Antibody


Anti-Casein Kinase Iα (F158) Antibody  的详细介绍
Name: Anti-Casein Kinase Iα (F158) Antibody
See all Casein Kinase Iα primary antibodies
Description: Rabbit polyclonal antibody to Casein Kinase Iα (F158)
Specificity: Casein Kinase Iα (F158) pAb detects endogenous levels of Casein Kinase Iα protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 150-200 of Human Casein Kinase Iα.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 42 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688).
Sequence Similarities: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Cellular Location: Cytoplasm. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Chromosome > Centromere > Kinetochore. Nucleus speckle.

Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).
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