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Anti-CASC3 Antibody

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Anti-CASC3 Antibody


Anti-CASC3 Antibody  的详细介绍
Name: Anti-CASC3 Antibody
See all CASC3 primary antibodies
Description: Rabbit polyclonal antibody to CASC3
Specificity: The antibody detects endogenous levels of total CASC3 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to residues near the C terminal of human ancer susceptibility candidate 3
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.1mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.
Tissue Specificity: Widely expressed. Overexpressed in breast cancers and metastasis, as well as in gastric cancers.
Sequence Similarities: Belongs to the CASC3 family.
Post-Translational Modification: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.
Cellular Location: Cytoplasm > Perinuclear region. Nucleus. Nucleus speckle.

Predominantly found in the perinuclear region (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress.
Database Links:
  • Entrez Gene: 22794?Human
  • Omim: 606504?Human
  • SwissProt: O15234?Human
  • Unigene: 592129?Human
    		•
    Synonyms:
  • Barentsz Antibody
  • Barentsz protein Antibody
  • Btz Antibody
  • Cancer susceptibility candidate 3 Antibody
  • Cancer susceptibility candidate gene 3 protein Antibody
  • CASC3 Antibody
  • CASC3_HUMAN Antibody
  • Metastatic lymph node 51 Antibody
  • Metastatic lymph node gene 51 protein Antibody
  • Metastatic lymph node protein 51 Antibody
  • MLN 51 Antibody
  • MLN 51 protein Antibody
  • MLN51 Antibody
  • MLN51/CASC3 Antibody
  • Protein barentsz Antibody
  • Protein CASC3 Antibody
  • Protein MLN 51 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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