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Anti-CAPS1 Antibody

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产品名称: Anti-CAPS1 Antibody
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简单介绍

Anti-CAPS1 Antibody


Anti-CAPS1 Antibody  的详细介绍
Name: Anti-CAPS1 Antibody
See all CAPS1 primary antibodies
Description: Rabbit polyclonal antibody to CAPS1
Specificity: Numerous isoforms of CAPS1 are known to exist. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 21 amino acid peptide near the amino terminus of the human CAPS1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering.
Tissue Specificity: Specifically expressed in neural and endocrine secretory tissues. Expressed in brain, pancreas, hypothalamus, pituitary and adrenal but not in heart, placenta, lung, liver, skeletal muscle or kidney. In brain, it is absent from the cell body layers of the hippocampus and dentate gyrus but abundant in the synaptic neuropil, except for the stratum lucidum and stratum lacunosum moleculare where it is not detected. In the cerebellum, it is mainly detected in the glomeruli of the granule cell layer where it colocalized with synaptophysin. In the olfactory bulb, it is detected mainly in the glomeruli. In the ***** adrenal gland, where it is restricted to the medulla (at protein level).
Cellular Location: Cytoplasmic vesicle membrane. Cell junction > Synapse.

Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2.
Database Links:
  • Entrez Gene: 8618?Human
  • Entrez Gene: 27062?Mouse
  • Entrez Gene: 26989?Rat
  • Omim: 604667?Human
  • SwissProt: Q9ULU8?Human
  • SwissProt: Q80TJ1?Mouse
  • SwissProt: Q62717?Rat
  • Unigene: 260881?Mouse
  • Unigene: 88197?Rat
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    Synonyms:
  • CADPS Antibody
  • CADPS1 Antibody
  • Calcium dependent secretion activator 1 Antibody
  • Calcium-dependent activator protein for secretion 1 Antibody
  • CAPS Antibody
  • CAPS1 Antibody
  • KIAA1121 Antibody
  • rCAPS Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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