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Anti-CAPN1 Antibody

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产品名称: Anti-CAPN1 Antibody
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简单介绍

Anti-CAPN1 Antibody


Anti-CAPN1 Antibody  的详细介绍
Name: Anti-CAPN1 Antibody
See all CAPN1 primary antibodies
Description: Rabbit polyclonal antibody to CAPN1
Specificity: CAPN1 pAb detects endogenous levels of CAPN1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant full length Human CAPN1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 82 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.
Function: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Tissue Specificity: Ubiquitous.
Involvement in Disease: Spastic paraplegia 76, autosomal recessive: A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Sequence Similarities: Belongs to the peptidase C2 family.
Post-Translational Modification: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Cellular Location: Cytoplasm. Cell membrane.

Translocates to the plasma membrane upon Ca(2+) binding. In granular keratinocytes and in lower corneocytes, colocalizes with FLG and FLG2 (PubMed:21531719).
Database Links:
  • Entrez Gene: 823?Human
  • Entrez Gene: 12333?Mouse
  • Entrez Gene: 29153?Rat
  • Omim: 114220?Human
  • SwissProt: P07384?Human
  • SwissProt: O35350?Mouse
  • SwissProt: P97571?Rat
  • Unigene: 502842?Human
  • Unigene: 6221?Mouse
  • Unigene: 6037?Rat
    		•
    Synonyms:
  • Ca2 activated neutral protease Antibody
  • Calcium activated neutral proteinase Antibody
  • Calcium activated neutral proteinase small subunit Antibody
  • Calcium dependent protease small subunit Antibody
  • Calcium dependent protease small subunit 1 Antibody
  • Calcium-activated neutral proteinase 1 Antibody
  • Calpain 1 Antibody
  • Calpain 1 large subunit Antibody
  • Calpain 1, (mu/I) large subunit Antibody
  • Calpain mu type Antibody
  • Calpain mu-type Antibody
  • Calpain regulatory subunit Antibody
  • Calpain small subunit 1 Antibody
  • Calpain, large polypeptide L1 Antibody
  • Calpain-1 catalytic subunit Antibody
  • Calpain-1 large subunit Antibody
  • CAN1_HUMAN Antibody
  • CANP Antibody
  • CANP 1 Antibody
  • CANP small subunit Antibody
  • CANP1 Antibody
  • CANPL 1 Antibody
  • CANPL1 Antibody
  • CAPN 1 Antibody
  • CAPN1 Antibody
  • Cell proliferation inducing protein 30 Antibody
  • Cell proliferation-inducing gene 30 protein Antibody
  • Micromolar Calpain Antibody
  • Micromolar-calpain Antibody
  • Mu Calpain Antibody
  • muCANP Antibody
  • muCL Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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