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Anti-CANX Antibody

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产品名称: Anti-CANX Antibody
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简单介绍

Anti-CANX Antibody


Anti-CANX Antibody  的详细介绍
Name: Anti-CANX Antibody
See all CANX primary antibodies
Description: Rabbit polyclonal antibody to CANX
Specificity: The antibody detects endogenous levels of total CANX protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Fusion protein corresponding to a region derived from internal residues of human calnexin
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.9mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Sequence Similarities: Belongs to the calreticulin family.
Post-Translational Modification: Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Cellular Location: Endoplasmic reticulum membrane. Endoplasmic reticulum. Melanosome.

Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).
Database Links:
  • Entrez Gene: 821?Human
  • Entrez Gene: 12330?Mouse
  • Omim: 114217?Human
  • SwissProt: P27824?Human
  • SwissProt: P35564?Mouse
  • Unigene: 567968?Human
  • Unigene: 248827?Mouse
    		•
    Synonyms:
  • Calnexin Antibody
  • CALX_HUMAN Antibody
  • CANX Antibody
  • CNX Antibody
  • FLJ26570 Antibody
  • Histocompatibility complex class I antigen binding protein p88 Antibody
  • IP90 Antibody
  • Major histocompatibility complex class I antigen-binding protein p88 Antibody
  • p90 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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