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Anti-CAMKK2 Antibody

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产品名称: Anti-CAMKK2 Antibody
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Anti-CAMKK2 Antibody


Anti-CAMKK2 Antibody  的详细介绍
Name: Anti-CAMKK2 Antibody
See all CAMKK2 primary antibodies
Description: Rabbit polyclonal antibody to CAMKK2
Specificity: The antibody detects endogenous levels of total CAMKK2 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human CAMKK2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
Tissue Specificity: Ubiquitously expressed with higher levels in the brain. Intermediate levels are detected in spleen, prostate, thyroid and leukocytes. The lowest level is in lung.
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Post-Translational Modification: Autophosphorylated and phosphorylated by PKA. Each isoform may show a different pattern of phosphorylation.
Cellular Location: Nucleus. Cytoplasm. Cell projection.

Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.
Database Links:
  • Entrez Gene: 10645?Human
  • Omim: 615002?Human
  • SwissProt: Q96RR4?Human
  • Unigene: 297343?Human
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    Synonyms:
  • Calcium/calmodulin dependent protein kinase beta Antibody
  • Calcium/calmodulin dependent protein kinase kinase 2 Antibody
  • Calcium/calmodulin dependent protein kinase kinase 2 beta Antibody
  • Calcium/calmodulin dependent protein kinase kinase beta Antibody
  • Calcium/calmodulin-dependent protein kinase kinase 2 Antibody
  • Calcium/calmodulin-dependent protein kinase kinase beta Antibody
  • CaM kinase kinase beta Antibody
  • CaM KK beta Antibody
  • CaM-kinase kinase 2 Antibody
  • CaM-kinase kinase beta Antibody
  • CaM-KK 2 Antibody
  • CaM-KK beta Antibody
  • CAMKK Antibody
  • CaMKK 2 Antibody
  • CaMKK beta Antibody
  • CAMKK beta protein Antibody
  • CAMKK2 Antibody
  • CAMKKB Antibody
  • KKCC2_HUMAN Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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