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Anti-CaMKIIβ/γ/δ (S280) Antibody

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产品名称: Anti-CaMKIIβ/γ/δ (S280) Antibody
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Anti-CaMKIIβ/γ/δ (S280) Antibody


Anti-CaMKIIβ/γ/δ (S280) Antibody  的详细介绍
Name: Anti-CaMKIIβ/γ/δ (S280) Antibody
See all CaMKIIβ primary antibodies
Description: Rabbit polyclonal antibody to CaMKIIβ/γ/δ (S280)
Specificity: CaMKIIβ/γ/δ (S280) pAb detects endogenous levels of CaMKIIβ/CaMKIIγ/CaMKIIδ protein.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 248-299of Human CaMKIIβ.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 50~80 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
Tissue Specificity: Expressed in skeletal muscle.
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Post-Translational Modification: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Cellular Location: Sarcoplasmic reticulum membrane.
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