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Anti-CaMKIIα (phospho-T286) Antibody

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产品名称: Anti-CaMKIIα (phospho-T286) Antibody
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Anti-CaMKIIα (phospho-T286) Antibody


Anti-CaMKIIα (phospho-T286) Antibody  的详细介绍
Name: Anti-CaMKIIα (phospho-T286) Antibody
See all CaMKIIα primary antibodies
Description: Rabbit polyclonal antibody to CaMKIIα (phospho-T286)
Specificity: p-CaMK2-a (T286) pAb detects endogenous levels of CaMK2-a protein only when phosphorylated at Thr286.
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human CaMKIIα around the phosphorylation site of Threonine 286.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 54 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Cellular Location: Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse.

Postsynaptic lipid rafts.
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