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Anti-CaMKII (Ab-286) Antibody

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产品名称: Anti-CaMKII (Ab-286) Antibody
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Anti-CaMKII (Ab-286) Antibody


Anti-CaMKII (Ab-286) Antibody  的详细介绍
Name: Anti-CaMKII (Ab-286) Antibody
See all CaMKII primary antibodies
Description: Rabbit polyclonal antibody to CaMKII (Ab-286)
Specificity: The antibody detects endogenous level of total CaMKII protein.
Applications: WB, IF
Dilutions: Western blotting: 1:500~1:1000 Immunofluorescence: 1:100~1:200
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around aa.284~288 (Q-E-T-V-D) derived from Human CaMKII.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration: 1.0mg / ml
Predicted MW: 50kd
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Cellular Location: Cell junction > Synapse > Presynaptic cell membrane. Cell junction > Synapse.

Postsynaptic lipid rafts.
Database Links:
  • Entrez Gene: 815 Human
  • Entrez Gene: 816 Human
  • Entrez Gene: 817 Human
  • Entrez Gene: 818 Human
  • Entrez Gene: 108058 Mouse
  • Entrez Gene: 12322 Mouse
  • Entrez Gene: 12323 Mouse
  • Entrez Gene: 12325 Mouse
  • Entrez Gene: 171140 Rat
  • Entrez Gene: 24245 Rat
  • Entrez Gene: 24246 Rat
  • Entrez Gene: 25400 Rat
  • Omim: 114078 Human
  • SwissProt: Q13554 Human
  • SwissProt: Q13555 Human
  • SwissProt: Q13557 Human
  • SwissProt: Q9UQM7 Human
  • SwissProt: P11798 Mouse
  • SwissProt: P28652 Mouse
  • SwissProt: Q6PHZ2 Mouse
  • SwissProt: Q923T9 Mouse
  • SwissProt: P08413 Rat
  • SwissProt: P11275 Rat
  • SwissProt: P11730 Rat
  • SwissProt: P15791 Rat
  • Unigene: 725992 Human
  • Unigene: 131530 Mouse
  • Unigene: 107499 Rat
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    Synonyms:
  • Calcium/calmodulin dependent protein kinase II alpha Antibody
  • Calcium/calmodulin dependent protein kinase II beta Antibody
  • Calcium/calmodulin dependent protein kinase II delta Antibody
  • Calcium/calmodulin dependent protein kinase II gamma Antibody
  • Calcium/calmodulin-dependent protein kinase type II subunit alpha Antibody
  • CaM kinase II Antibody
  • CaM kinase II alpha Antibody
  • CaM kinase II beta Antibody
  • CaM kinase II delta Antibody
  • CaM kinase II gamma Antibody
  • CaM kinase II subunit alpha Antibody
  • CaMK-II subunit alpha Antibody
  • CAMK2 Antibody
  • Camk2a Antibody
  • CAMK2B Antibody
  • CAMK2D Antibody
  • CAMK2G Antibody
  • CAMKA Antibody
  • CaMKII Antibody
  • KCC2A_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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