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Anti-CAD Antibody

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产品名称: Anti-CAD Antibody
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简单介绍

Anti-CAD Antibody


Anti-CAD Antibody  的详细介绍
Name: Anti-CAD Antibody
See all CAD primary antibodies
Description: Rabbit polyclonal antibody to CAD
Applications: E, WB, IHC
Reactivity: Mouse
Immunogen: Raised against a peptide corresponding to amino acids 314 to 329 of murine CAD.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Sequence Similarities: In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.
Post-Translational Modification: Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivy to feedback inhibition by UTP (By similarity).
Cellular Location: Cytoplasm. Nucleus.

Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Database Links:
  • Entrez Gene: 69719?Mouse
  • SwissProt: B2RQC6?Mouse
    		•
    Synonyms:
  • Aspartate carbamoyltransferase Antibody
  • Aspartate transcarbamylase Antibody
  • CAD Antibody
  • CAD protein Antibody
  • CAD trifunctional protein Antibody
  • Carbamoyl phosphate synthetase 2 Antibody
  • Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase Antibody
  • CPSase ATCase DHOase Antibody
  • Dihydroorotase Antibody
  • Glutamine dependent carbamoyl phosphate synthase Antibody
  • Multifunctional protein CAD Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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