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Anti-CAD Antibody

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产品名称: Anti-CAD Antibody
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简单介绍

Anti-CAD Antibody


Anti-CAD Antibody  的详细介绍
Name: Anti-CAD Antibody
See all CAD primary antibodies
Description: Rabbit polyclonal antibody to CAD
Applications: WB, IHC
Reactivity: Human
Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1625 and 1900 of Human CAD
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
Involvement in Disease: Congenital disorder of glycosylation 1Z: A form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1Z patients show abnormal glycosylation of red blood cell proteins, but glycosylation of serum transferrin is normal.
Sequence Similarities: In the central section; belongs to the DHOase family.
Post-Translational Modification: Activated by MAP kinase (Erk1/2) phosphorylation just prior to the S phase of the cell cycle, when the demand for pyrimidine nucleotides is greatest, and down-regulated as the cells emerge from S phase by protein kinase A (PKA) phosphorylation. Phosphorylation at Ser-1859 by RPS6KB1 downstream of MTOR promotes oligomerization and stimulates dihydroorotase activity. Phosphorylation at Ser-1406 reduces sensitivy to feedback inhibition by UTP.
Cellular Location: Cytoplasm. Nucleus.

Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.
Database Links:
  • Entrez Gene: 790?Human
  • Omim: 114010?Human
  • SwissProt: P27708?Human
  • Unigene: 377010?Human
    		•
    Synonyms:
  • Aspartate carbamoyltransferase Antibody
  • Aspartate transcarbamylase Antibody
  • CAD Antibody
  • CAD protein Antibody
  • CAD trifunctional protein Antibody
  • Carbamoyl phosphate synthetase 2 Antibody
  • Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase Antibody
  • CPSase ATCase DHOase Antibody
  • Dihydroorotase Antibody
  • Glutamine dependent carbamoyl phosphate synthase Antibody
  • Multifunctional protein CAD Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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