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Anti-CACNA1G Antibody

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产品名称: Anti-CACNA1G Antibody
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Anti-CACNA1G Antibody


Anti-CACNA1G Antibody  的详细介绍
Name: Anti-CACNA1G Antibody
See all CACNA1G primary antibodies
Description: Rabbit polyclonal antibody to CACNA1G
Specificity: The antibody detects endogenous levels of total CACNA1G protein.
Applications: IHC
Reactivity: Human
Immunogen: Synthetic peptide corresponding to residues near the C terminal of human calcium channel, voltage-dependent, T type, alpha 1G subunit
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.9mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Tissue Specificity: Highly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus. Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression.
Involvement in Disease: Spinocerebellar ataxia 42: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA42 is a slowly progressive, autosomal dominant form with variable severity.
Sequence Similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1G subfamily.
Post-Translational Modification: In response to raising of intracellular calcium, the T-type channels are activated by CaM-kinase II.
Cellular Location: Cell membrane. Cytoplasm.
Database Links:
  • Entrez Gene: 8913?Human
  • Omim: 604065?Human
  • SwissProt: O43497?Human
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    Synonyms:
  • CACNA1G Antibody
  • calcium channel voltage dependent alpha 1G subunit Antibody
  • calcium channel voltage dependent T type alpha 1G subunit Antibody
  • calcium channel voltage dependent T type alpha1G subunit Antibody
  • CaV T1 Antibody
  • Cav3 1 Antibody
  • cav3 1c Antibody
  • KIAA1123 Antibody
  • MGC117234 Antibody
  • NBR13 Antibody
  • voltage dependent calcium channel alpha 1G subunit isoform 11 Antibody
  • voltage dependent T type calcium channel subunit alpha 1G Antibody
  • Voltage gated calcium channel subunit alpha Cav3 1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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