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Anti-CABLES1 Antibody

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产品名称: Anti-CABLES1 Antibody
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Anti-CABLES1 Antibody


Anti-CABLES1 Antibody  的详细介绍
Name: Anti-CABLES1 Antibody
See all CABLES1 primary antibodies
Description: Rabbit polyclonal antibody to CABLES1
Specificity: The antibody detects endogenous levels of total CABLES1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Fusion protein corresponding to residues near the C terminal of human Cdk5 and Abl enzyme substrate 1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 0.7mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).
Tissue Specificity: Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers.
Sequence Similarities: Belongs to the cyclin family.
Post-Translational Modification: Phosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity).
Cellular Location: Nucleus. Cytoplasm.

Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity).
Database Links:
  • Entrez Gene: 91768?Human
  • Entrez Gene: 63955?Mouse
  • Omim: 609194?Human
  • SwissProt: Q8TDN4?Human
  • SwissProt: Q9ESJ1?Mouse
  • Unigene: 11108?Human
  • Unigene: 40717?Mouse
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    Synonyms:
  • CABL1_HUMAN Antibody
  • CABLES Antibody
  • CABLES1 Antibody
  • Cdk5 and Abl enzyme substrate 1 Antibody
  • CDK5 and ABL1 enzyme substrate 1 Antibody
  • FLJ35924 Antibody
  • HsT2563 Antibody
  • IK3 1 Antibody
  • Ik3-1 Antibody
  • Interactor with CDK3 1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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