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Anti-CA II (N229) Antibody

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产品名称: Anti-CA II (N229) Antibody
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Anti-CA II (N229) Antibody


Anti-CA II (N229) Antibody  的详细介绍
Name: Anti-CA II (N229) Antibody
See all CA II primary antibodies
Description: Rabbit polyclonal antibody to CA II (N229)
Specificity: CA II (N229) pAb detects endogenous levels of CA II protein.
Applications: WB, IHC
Reactivity: Human, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 201-250 of Human CA II.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 28 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Involvement in Disease: Osteopetrosis, autosomal recessive 3: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or *****hood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.
Sequence Similarities: Belongs to the alpha-carbonic anhydrase family.
Cellular Location: Cytoplasm. Cell membrane.

Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.
Database Links:
  • Entrez Gene: 760?Human
  • Entrez Gene: 54231?Rat
  • Omim: 611492?Human
  • SwissProt: P00918?Human
  • SwissProt: P27139?Rat
  • Unigene: 155097?Human
  • Unigene: 26083?Rat
    		•
    Synonyms:
  • CA 2 Antibody
  • CA II Antibody
  • CA-II Antibody
  • Ca2 Antibody
  • CAC Antibody
  • CAH2_HUMAN Antibody
  • CAII Antibody
  • Car 2 Antibody
  • Car2 Antibody
  • Carbonate dehydratase II Antibody
  • Carbonic anhydrase 2 Antibody
  • Carbonic anhydrase B Antibody
  • Carbonic anhydrase C Antibody
  • Carbonic anhydrase C, formerly Antibody
  • Carbonic Anhydrase II Antibody
  • Carbonic dehydratase Antibody
  • epididymis luminal protein 76 Antibody
  • Epididymis secretory protein Li 282 Antibody
  • HEL-76 Antibody
  • HEL-S-282 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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