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Anti-C5aR (S334) Antibody

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产品名称: Anti-C5aR (S334) Antibody
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Anti-C5aR (S334) Antibody


Anti-C5aR (S334) Antibody  的详细介绍
Name: Anti-C5aR (S334) Antibody
See all C5aR primary antibodies
Description: Rabbit polyclonal antibody to C5aR (S334)
Specificity: CD88/C5aR (S334) pAb detects endogenous levels of D88/C5aR protein.
Applications: IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 300-350 of Human C5aR.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification: Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
Cellular Location: Cell membrane. Cytoplasmic vesicle.

Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
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