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Anti-BRMS-1 (E43) Antibody

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产品名称: Anti-BRMS-1 (E43) Antibody
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Anti-BRMS-1 (E43) Antibody


Anti-BRMS-1 (E43) Antibody  的详细介绍
Name: Anti-BRMS-1 (E43) Antibody
See all BRMS1 primary antibodies
Description: Rabbit polyclonal antibody to BRMS-1 (E43)
Specificity: BRMS-1 (E43) pAb detects endogenous levels of BRMS-1 protein
Applications: WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 210-58 of Human BRMS-1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 28 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.
Tissue Specificity: Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies.
Sequence Similarities: Belongs to the BRMS1 family.
Post-Translational Modification: Ubiquitinated by a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing SPOP, leading to proteasomal degradation.
Cellular Location: Nucleus. Cytoplasm.

Predominantly nuclear.
Database Links:
  • Entrez Gene: 25855?Human
  • Entrez Gene: 107392?Mouse
  • Entrez Gene: 293668?Rat
  • Omim: 606259?Human
  • SwissProt: Q9HCU9?Human
  • SwissProt: Q99N20?Mouse
  • SwissProt: Q5M7T3?Rat
  • Unigene: 100426?Human
  • Unigene: 2839?Rat
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    Synonyms:
  • AV003220 Antibody
  • AW554636 Antibody
  • Breast cancer metastasis suppressor 1 Antibody
  • Breast cancer metastasis-suppressor 1 Antibody
  • BRMS1 Antibody
  • BRMS1_HUMAN Antibody
  • DKFZp564A063 Antibody
  • MGC95128 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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