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Anti-BRF2 Antibody

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产品名称: Anti-BRF2 Antibody
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简单介绍

Anti-BRF2 Antibody


Anti-BRF2 Antibody  的详细介绍
Name: Anti-BRF2 Antibody
See all BRF2 primary antibodies
Description: Goat polyclonal antibody to BRF2.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human BRF2 (C terminal).
Sequence: C-QAARQAATSVPNPP
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071).
Sequence Similarities: Belongs to the TFIIB family.
Post-Translational Modification: In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 55290 Human
  • Omim: 607013 Human
  • SwissProt: Q9HAW0 Human
  • Unigene: 726335 Human
    		•
    Synonyms:
  • B-related factor 2 Antibody
  • BRF-2 Antibody
  • BRF2 Antibody
  • BRF2_HUMAN Antibody
  • BRFU Antibody
  • FLJ11052 Antibody
  • hBRFU Antibody
  • hTFIIIB50 Antibody
  • RNA polymerase III transcription initiation factor BRF2 Antibody
  • TFIIIB50 Antibody
  • Transcription factor IIB- related factor TFIIIB50 Antibody
  • Transcription factor IIIB 50 kDa subunit Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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