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Anti-BRE Antibody

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Anti-BRE Antibody


Anti-BRE Antibody  的详细介绍
Name: Anti-BRE Antibody
See all BRE primary antibodies
Description: Rabbit polyclonal antibody to BRE
Specificity: The antibody detects endogenous levels of total BRE protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Fusion protein corresponding to a region derived from internal residues of human brain and reproductive organ-expressed (TNFRSF1A modulator)
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.5mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).
Tissue Specificity: Expressed in all cell lines examined. Highly expressed in placenta.
Sequence Similarities: Belongs to the BRE family.
Cellular Location: Cytoplasm. Nucleus.

Localizes at sites of DNA damage at double-strand breaks (DSBs).
Database Links:
  • Entrez Gene: 9577?Human
  • Omim: 610497?Human
  • SwissProt: Q9NXR7?Human
  • Unigene: 258314?Human
    		•
    Synonyms:
  • 6030405P19Rik Antibody
  • AI429776 Antibody
  • B830038C02Rik Antibody
  • Brain and reproductive organ expressed (TNFRSF1A modulator) Antibody
  • brain and reproductive organ expressed protein Antibody
  • Brain and reproductive organ-expressed protein Antibody
  • BRCA1 A complex subunit BRE Antibody
  • BRCA1-A complex subunit BRE Antibody
  • BRCA1/BRCA2 containing complex subunit 4 Antibody
  • BRCA1/BRCA2 containing complex subunit 45 Antibody
  • BRCA1/BRCA2-containing complex subunit 45 Antibody
  • BRCC4 Antibody
  • BRCC45 Antibody
  • bre Antibody
  • BRE_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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