产品资料

Anti-BRCA1 Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-BRCA1 Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-BRCA1 Antibody


Anti-BRCA1 Antibody  的详细介绍
Name: Anti-BRCA1 Antibody
See all BRCA1 primary antibodies
Description: Rabbit polyclonal antibody to BRCA1
Specificity: BRCA1 Polyclonal Antibody detects endogenous levels of BRCA1 protein.
Applications: WB, IHC, ELISA
Reactivity: Human
Immunogen: Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of S1524.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20?C / 1 year
Function: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator (PubMed:20160719).
Tissue Specificity: Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
Involvement in Disease: Breast cancer: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.

Breast-ovarian cancer, familial, 1: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate.

Ovarian cancer: The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Pancreatic cancer 4: A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
Post-Translational Modification: Phosphorylation at Ser-308 by AURKA is required for normal cell cycle progression from G2 to mitosis. Phosphorylated in response to IR, UV, and various stimuli that cause checkpoint activation, probably by ATM or ATR. Phosphorylation at Ser-988 by CHEK2 regulates mitotic spindle assembly.
Cellular Location: Nucleus. Chromosome. Cytoplasm.

Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by FAM175A and the BRCA1-A complex (PubMed:26778126). Translocated to the cytoplasm during UV-induced apoptosis (PubMed:20160719).
Database Links:
  • Entrez Gene: 672?Human
  • Omim: 113705?Human
  • SwissProt: P38398?Human
  • Unigene: 194143?Human
    		•
    Synonyms:
  • BRCA 1 Antibody
  • BRCA1 Antibody
  • BRCA1 DNA repair associated Antibody
  • BRCA1/BRCA2 containing complex subunit 1 Antibody
  • BRCA1/BRCA2-containing complex, subunit 1 Antibody
  • BRCA1_HUMAN Antibody
  • BRCAI Antibody
  • BRCC 1 Antibody
  • BRCC1 Antibody
  • Breast and ovarian cancer susceptibility protein 1 Antibody
  • Breast Cancer 1 Antibody
  • Breast Cancer 1 Early Onset Antibody
  • Breast cancer type 1 susceptibility protein Antibody
  • BROVCA1 Antibody
  • FANCS Antibody
  • IRIS Antibody
  • PNCA4 Antibody
  • PPP1R53 Antibody
  • Protein phosphatase 1 regulatory subunit 53 Antibody
  • PSCP Antibody
  • RING finger protein 53 Antibody
  • RNF53 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号