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Anti-Bone morphogenetic protein 2 Antibody

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产品名称: Anti-Bone morphogenetic protein 2 Antibody
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Anti-Bone morphogenetic protein 2 Antibody


Anti-Bone morphogenetic protein 2 Antibody  的详细介绍
Name: Anti-Bone morphogenetic protein 2 Antibody
See all Bone morphogenetic protein 2 primary antibodies
Description: Rabbit polyclonal antibody to Bone morphogenetic protein 2
Specificity: The antibody detects endogenous level of total Bone morphogenetic protein 2 polyclonal antibody.
Applications: IHC
Reactivity: Human
Immunogen: Recombinant human Bone morphogenetic protein 2 protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration: 1.0mg / mL
Formulation: Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage: Store at -20?C
Function: Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Tissue Specificity: Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Sequence Similarities: Belongs to the TGF-beta family.
Cellular Location: Secreted.
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