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Anti-Bnip3L Antibody

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产品名称: Anti-Bnip3L Antibody
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简单介绍

Anti-Bnip3L Antibody


Anti-Bnip3L Antibody  的详细介绍
Name: Anti-Bnip3L Antibody
See all Bnip3L primary antibodies
Description: Rabbit polyclonal antibody to Bnip3L
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Raised against a peptide corresponding to amino acids 77 to 92 of human origin, which are identical to those of mouse Bnip3L.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Sequence Similarities: Belongs to the NIP3 family.
Post-Translational Modification: Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
Cellular Location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane.

Colocalizes with SPATA18 at the mitochondrion outer membrane.
Database Links:
  • Entrez Gene: 665?Human
  • Omim: 605368?Human
  • SwissProt: O60238?Human
  • Unigene: 131226?Human
    		•
    Synonyms:
  • Adenovirus E1B19k binding protein B5 Antibody
  • Adenovirus E1B19K-binding protein B5 Antibody
  • BCL2/adenovirus E1B 19 kd protein interacting protein 3a Antibody
  • BCL2/adenovirus E1B 19 kDa protein interacting protein 3A Antibody
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Antibody
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A Antibody
  • BCL2/adenovirus E1B 19kDa interacting protein 3 like Antibody
  • BNI3L_HUMAN Antibody
  • BNIP3a Antibody
  • BNIP3H Antibody
  • BNIP3L Antibody
  • BNIP3L protein Antibody
  • NIP3 like protein X Antibody
  • NIP3-like protein X Antibody
  • NIP3L Antibody
  • NIX Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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