产品资料

Anti-BNIP3L Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-BNIP3L Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-BNIP3L Antibody


Anti-BNIP3L Antibody  的详细介绍
Name: Anti-BNIP3L Antibody
See all BNIP3L primary antibodies
Description: Rabbit polyclonal antibody to BNIP3L
Specificity: The antibody detects endogenous levels of total BNIP3L protein.
Applications: IHC
Reactivity: Human, Mouse
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human BCL2 / adenovirus E1B 19kDa interacting protein 3-like
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.6mg / ml
Formulation: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage: Store at -20?C
Function: Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
Sequence Similarities: Belongs to the NIP3 family.
Post-Translational Modification: Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
Cellular Location: Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane.

Colocalizes with SPATA18 at the mitochondrion outer membrane.
Database Links:
  • Entrez Gene: 665?Human
  • Entrez Gene: 12177?Mouse
  • Omim: 605368?Human
  • SwissProt: O60238?Human
  • SwissProt: Q9Z2F7?Mouse
  • Unigene: 131226?Human
  • Unigene: 29820?Mouse
  • Unigene: 347081?Mouse
    		•
    Synonyms:
  • Adenovirus E1B19k binding protein B5 Antibody
  • Adenovirus E1B19K-binding protein B5 Antibody
  • BCL2/adenovirus E1B 19 kd protein interacting protein 3a Antibody
  • BCL2/adenovirus E1B 19 kDa protein interacting protein 3A Antibody
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Antibody
  • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A Antibody
  • BCL2/adenovirus E1B 19kDa interacting protein 3 like Antibody
  • BNI3L_HUMAN Antibody
  • BNIP3a Antibody
  • BNIP3H Antibody
  • BNIP3L Antibody
  • BNIP3L protein Antibody
  • NIP3 like protein X Antibody
  • NIP3-like protein X Antibody
  • NIP3L Antibody
  • NIX Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号