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Anti-BMP10 Antibody

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产品名称: Anti-BMP10 Antibody
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简单介绍

Anti-BMP10 Antibody


Anti-BMP10 Antibody  的详细介绍
Name: Anti-BMP10 Antibody
See all BMP10 primary antibodies
Description: Rabbit polyclonal antibody to BMP10
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 360 and 421 of BMP10
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Purified by antigen-affinity chromatography.
Formulation: Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage: Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.
Function: Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
Tissue Specificity: Detected in mammary epithelia (at protein level).
Sequence Similarities: Belongs to the TGF-beta family.
Cellular Location: Secreted.
Database Links:
  • Entrez Gene: 27302?Human
  • Omim: 608748?Human
  • SwissProt: O95393?Human
  • Unigene: 158317?Human
    		•
    Synonyms:
  • BMP-10 Antibody
  • BMP10 Antibody
  • BMP10_HUMAN Antibody
  • Bone morphogenetic protein 10 Antibody
  • Bone morphogenetic protein 10 preproprotein Antibody
  • MGC126783 Antibody
  • OTTHUMP00000159973 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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