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Anti-BIRC7 Antibody

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产品名称: Anti-BIRC7 Antibody
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Anti-BIRC7 Antibody


Anti-BIRC7 Antibody  的详细介绍
Name: Anti-BIRC7 Antibody
See all BIRC7 primary antibodies
Description: Rabbit polyclonal antibody to BIRC7
Specificity: The antibody detects endogenous level of total BIRC7 protein.
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Full length fusion protein
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Formulation: Supplied at 0.6mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Isoform 2 protects against natural killer (NK) cell killing whereas isoform 1 augments killing.
Tissue Specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most ***** tissues. Detected in ***** heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in ***** brain, skeletal muscle and peripheral blood leukocytes.
Sequence Similarities: Belongs to the IAP family.
Post-Translational Modification: Autoubiquitinated and undergoes proteasome-mediated degradation.
Cellular Location: Nucleus. Cytoplasm. Golgi apparatus.

Nuclear, and in a filamentous pattern throughout the cytoplasm. Full-length livin is detected exclusively in the cytoplasm, whereas the truncated form (tLivin) is found in the peri-nuclear region with marked localization to the Golgi apparatus; the accumulation of tLivin in the nucleus shows positive correlation with the increase in apoptosis.
Database Links:
  • Entrez Gene: 79444?Human
  • Omim: 605737?Human
  • SwissProt: Q96CA5?Human
  • Unigene: 256126?Human
    		•
    Synonyms:
  • Baculoviral IAP repeat containing 7 Antibody
  • Baculoviral IAP repeat containing protein 7 Antibody
  • Baculoviral IAP repeat-containing protein 7 Antibody
  • BIRC 7 Antibody
  • birc7 Antibody
  • BIRC7_HUMAN Antibody
  • KIAP Antibody
  • Kidney inhibitor of apoptosis protein Antibody
  • Livin Antibody
  • Livin inhibitor of apotosis Antibody
  • Melanoma inhibitor of apoptosis protein Antibody
  • ML IAP Antibody
  • ML-IAP Antibody
  • MLIAP Antibody
  • RING finger protein 50 Antibody
  • RNF 50 Antibody
  • RNF50 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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