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Anti-BIG2 (L1527) Antibody

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产品名称: Anti-BIG2 (L1527) Antibody
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Anti-BIG2 (L1527) Antibody


Anti-BIG2 (L1527) Antibody  的详细介绍
Name: Anti-BIG2 (L1527) Antibody
See all BIG2 primary antibodies
Description: Rabbit polyclonal antibody to BIG2 (L1527)
Specificity: BIG2 (L1527) pAb detects endogenous levels of BIG2 protein.
Applications: WB, IHC, IF
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 1500-1550 of Human BIG2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Molecular Weight: ~ 210 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Function: Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
Tissue Specificity: Expressed in placenta, lung, heart, brain, kidney and pancreas.
Involvement in Disease: Periventricular nodular heterotopia 2: A developmental disorder characterized by the presence of periventricular nodules of cerebral gray matter, resulting from a failure of neurons to migrate normally from the lateral ventricular proliferative zone, where they are formed, to the cerebral cortex. PVNH2 is an autosomal recessive form characterized by microcephaly (small brain), severe developmental delay and recurrent infections. No anomalies extrinsic to the central nervous system, such as dysmorphic features or grossly abnormal endocrine or other conditions, are associated with PVNH2.
Post-Translational Modification: In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.
Cellular Location: Cytoplasm. Membrane. Golgi apparatus. Cytoplasm > Perinuclear region. Golgi apparatus > trans-Golgi network. Endosome. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cell projection > Dendrite. Cytoplasmic vesicle. Cell junction > Synapse. Cytoplasm > Cytoskeleton.

Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes.
Database Links:
  • Entrez Gene: 10564?Human
  • Entrez Gene: 99371?Mouse
  • Entrez Gene: 296380?Rat
  • Omim: 605371?Human
  • SwissProt: Q9Y6D5?Human
  • SwissProt: A2A5R2?Mouse
  • SwissProt: Q7TSU1?Rat
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    Synonyms:
  • ADP ribosylation factor guanine nucleotide exchange factor 2 Antibody
  • ADP ribosylation factor guanine nucleotide exchange factor 2 (brefeldin A inhibited) Antibody
  • ARFGEF 2 Antibody
  • ARFGEF2 Antibody
  • ARFGEP2 Antibody
  • BIG 2 Antibody
  • BIG2 Antibody
  • Brefeldin A inhibited 2 Antibody
  • Brefeldin A inhibited GEP 2 Antibody
  • Brefeldin A inhibited guanine nucleotide exchange protein 2 Antibody
  • dJ1164I10.1 Antibody
  • FLJ23723 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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