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Anti-Bif Antibody

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Anti-Bif Antibody


Anti-Bif Antibody  的详细介绍
Name: Anti-Bif Antibody
See all Bif primary antibodies
Description: Rabbit polyclonal antibody to Bif
Applications: E, WB, ICC
Reactivity: Human, Mouse
Immunogen: Raised against a 15 amino acid peptide from near the carboxy terminus of human BIF.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (PubMed:17086176). May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (PubMed:24523556). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (PubMed:24523556).
Tissue Specificity: Isoform 1 is widely expressed. Isoform 2 is brain-specific. Isoform 3 is predominantly expressed in testis, but it is also detected in liver and, at much lower levels, in skin, stomach and ovary.
Sequence Similarities: Belongs to the endophilin family.
Post-Translational Modification: Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization.
Cellular Location: Cytoplasm. Golgi apparatus membrane. Mitochondrion outer membrane. Cytoplasmic vesicle > Autophagosome membrane. Midbody.

Association with the Golgi apparatus depends on the cell type. Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes.
Database Links:
  • Entrez Gene: 51100 Human
  • Entrez Gene: 54673 Mouse
  • Omim: 609287 Human
  • SwissProt: Q9Y371 Human
  • SwissProt: Q9JK48 Mouse
  • Unigene: 136309 Human
  • Unigene: 271775 Mouse
  • Unigene: 440295 Mouse
    		•
    Synonyms:
  • Bax interacting factor 1 Antibody
  • Bax-interacting factor 1 Antibody
  • Bif Antibody
  • Bif 1 Antibody
  • Bif-1 Antibody
  • CGI 61 Antibody
  • dJ612B15.2 Antibody
  • Endophilin B1 Antibody
  • Endophilin-B1 Antibody
  • PPP1R70 Antibody
  • Protein phosphatase 1 regulatory subunit 70 Antibody
  • SH3 containing protein SH3GLB1 Antibody
  • SH3 domain GRB2 like endophilin B1 Antibody
  • SH3 domain-containing GRB2-like protein B1 Antibody
  • Sh3glb1 Antibody
  • SH3p13 Antibody
  • SHLB1_HUMAN Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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