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Anti-BHLHE40 Antibody

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产品名称: Anti-BHLHE40 Antibody
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Anti-BHLHE40 Antibody


Anti-BHLHE40 Antibody  的详细介绍
Name: Anti-BHLHE40 Antibody
See all BHLHE40 primary antibodies
Description: Rabbit polyclonal antibody to BHLHE40
Specificity: The antibody detects endogenous level of total BHLHE40 antibody.
Applications: WB, IF
Reactivity: Human
Immunogen: Recombinant protein of human BHLHE40.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were purified by affinity purification using immunogen.
Concentration: 1.0mg / ml
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20˚C
Function: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
Tissue Specificity: Expressed in cartilage, spleen, intestine, lung, and to a lesser extent in heart, brain, liver, muscle and stomach.
Post-Translational Modification: Ubiquitinated; which may lead to proteasomal degradation.
Cellular Location: Cytoplasm. Nucleus.

Predominantly localized in the nucleus (PubMed:11278694).
Database Links:
  • Entrez Gene: 8553 Human
  • Omim: 604256 Human
  • SwissProt: O14503 Human
  • Unigene: 171825 Human
    		•
    Synonyms:
  • BHLHB2 Antibody
  • bHLHe40 Antibody
  • Class B Basic Helix Loop Helix Protein 2 Antibody
  • Class E basic helix loop helix protein 40 Antibody
  • Clast5 Antibody
  • DEC1 Antibody
  • Differentially expressed in chondrocytes protein 1 Antibody
  • E47 interaction protein 1 Antibody
  • EIP1 Antibody
  • Enhancer of split and hairy related protein 2 Antibody
  • SHARP 2 Antibody
  • SHARP2 Antibody
  • Stimulated by retinoic acid gene 13 protein Antibody
  • STRA13 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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