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Anti-BCL2L11 Antibody

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产品名称: Anti-BCL2L11 Antibody
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简单介绍

Anti-BCL2L11 Antibody


Anti-BCL2L11 Antibody  的详细介绍
Name: Anti-BCL2L11 Antibody
See all BCL2L11 primary antibodies
Description: Rabbit polyclonal antibody to BCL2L11
Specificity: The antibody detects endogenous levels of total BCL2L11 protein.
Applications: IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide of human BCL2L11
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 1.8mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.
Tissue Specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylation at Ser-69 by MAPK1/MAPK3 leads to interaction with TRIM2 and polyubiquitination, followed by proteasomal degradation (PubMed:15486195, PubMed:21478148). Deubiquitination catalyzed by USP27X stabilizes the protein (By similarity).
Cellular Location: Endomembrane system.

Associated with intracytoplasmic membranes.
Database Links:
  • Entrez Gene: 10018?Human
  • Entrez Gene: 12125?Mouse
  • Entrez Gene: 64547?Rat
  • Omim: 603827?Human
  • SwissProt: O43521?Human
  • SwissProt: O54918?Mouse
  • SwissProt: O88498?Rat
  • Unigene: 469658?Human
  • Unigene: 141083?Mouse
  • Unigene: 453214?Mouse
  • Unigene: 82709?Rat
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    Synonyms:
  • BCL2 like 11 Antibody
  • B2L11_HUMAN Antibody
  • BAM Antibody
  • Bcl 2 interacting protein Bim Antibody
  • Bcl 2 related ovarian death agonist Antibody
  • Bcl-2-like protein 11 Antibody
  • BCL2 interacting mediator of cell death Antibody
  • BCL2 like 11 (apoptosis facilitator) Antibody
  • BCL2 like protein 11 Antibody
  • Bcl2-interacting mediator of cell death Antibody
  • Bcl2-L-11 Antibody
  • Bcl2l11 Antibody
  • Bim Antibody
  • BIM alpha6 Antibody
  • BIM beta6 Antibody
  • BIM beta7 Antibody
  • BimEL Antibody
  • BimL Antibody
  • BOD Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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