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Anti-BCL10 Antibody

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Anti-BCL10 Antibody


Anti-BCL10 Antibody  的详细介绍
Name: Anti-BCL10 Antibody
See all BCL10 primary antibodies
Description: Rabbit polyclonal antibody to BCL10.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human BCL10.
Protein Length: 233
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Involved in adaptive immune response (PubMed:25365219). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 (PubMed:18264101).
Tissue Specificity: Ubiquitous.
Involvement in Disease: Immunodeficiency 37: A form of primary combined immunodeficiency, a group of disorders characterized by severe recurrent infections, with normal numbers or an absence of T and B lymphocytes, and impaired cellular and humoral immunity. IMD37 is characterized by hypogammaglobulinemia without lymphopenia, but with profoundly reduced memory B cells and memory T cells, and increased numbers of circulating naive lymphocytes. Inheritance is autosomal recessive.

Lymphoma, mucosa-associated lymphoid type: A subtype of non-Hodgkin lymphoma, originating in mucosa-associated lymphoid tissue. MALT lymphomas occur most commonly in the gastro-intestinal tract but have been described in a variety of extranodal sites including the ocular adnexa, salivary gland, thyroid, lung, thymus, and breast. Histologically, they are characterized by an infiltrate of small to medium-sized lymphocytes with abundant cytoplasm and irregularly shaped nuclei. Scattered transformed blasts (large cells) also are present. Non-malignant reactive follicles are observed frequently. A pivotal feature is the presence of lymphoepithelial lesions, with invasion and partial destruction of mucosal glands and crypts by aggregates of tumor cells.
Post-Translational Modification: Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
Cellular Location: Cytoplasm > Perinuclear region. Membrane raft.

Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.
Database Links:
  • Entrez Gene: 8915?Human
  • Entrez Gene: 12042?Mouse
  • Entrez Gene: 83477?Rat
  • Omim: 603517?Human
  • SwissProt: O95999?Human
  • SwissProt: Q9Z0H7?Mouse
  • SwissProt: Q9QYN5?Rat
  • Unigene: 193516?Human
  • Unigene: 239141?Mouse
  • Unigene: 13007?Rat
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    Synonyms:
  • AI132454 Antibody
  • B cell CLL/lymphoma 10 Antibody
  • B cell lymphoma/leukemia10 Antibody
  • B-cell CLL/lymphoma 10 Antibody
  • B-cell leukemia/lymphoma 10 Antibody
  • B-cell lymphoma/leukemia 10 Antibody
  • Bcl 10 Antibody
  • Bcl-10 Antibody
  • Bcl10 Antibody
  • BCL10_HUMAN Antibody
  • c E10 Antibody
  • c-E10 Antibody
  • C81403 Antibody
  • CARD containing apoptotic signaling protein Antibody
  • CARD containing molecule enhancing NF kappa B Antibody
  • CARD containing molecule enhancing NF kB Antibody
  • CARD containing molecule enhancing NF-kB Antibody
  • CARD containing molecule enhancing NFkB Antibody
  • CARD containing proapoptotic protein Antibody
  • CARD like apoptotic protein Antibody
  • CARD-containing apoptotic signaling protein Antibody
  • CARD-containing molecule enhancing NF-kappa-B Antibody
  • CARD-containing proapoptotic protein Antibody
  • CARD-like apoptotic protein Antibody
  • CARMEN Antibody
  • Caspase recruiting domain containing protein Antibody
  • caspase-recruiting domain-containing protein Antibody
  • cCARMEN Antibody
  • cE 10 Antibody
  • cE10 Antibody
  • CED 3/ICH 1 prodomain homologous E10 like regulator Antibody
  • CED-3/ICH-1 prodomain homologous E10-like regulator Antibody
  • CED3/ICH1 prodomain homologous E10 like regulator Antibody
  • Cellular E10 Antibody
  • Cellular homolog of vCARMEN Antibody
  • Cellular-E10 Antibody
  • CIPER Antibody
  • CLAP Antibody
  • hCLAP Antibody
  • Mammalian CARD containing adapter molecule E10 Antibody
  • Mammalian CARD-containing adapter molecule E10 Antibody
  • mE 10 Antibody
  • mE10 Antibody
  • R-RCD1 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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