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Anti-Bcl-2 Antibody

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产品名称: Anti-Bcl-2 Antibody
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Anti-Bcl-2 Antibody


Anti-Bcl-2 Antibody  的详细介绍
Name: Anti-Bcl-2 Antibody
See all Bcl-2 primary antibodies
Description: Rabbit polyclonal antibody to Bcl-2
Applications: E, WB, ICC
Reactivity: Human
Immunogen: Raised against a peptide corresponding to 14 amino acids near the middle of human Bcl-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Ion exchange chromatography purified
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785).
Tissue Specificity: Expressed in a variety of tissues.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-87, wich stimulates starvation-induced autophagy. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Cellular Location: Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Database Links:
  • Entrez Gene: 596 Human
  • Omim: 151430 Human
  • SwissProt: P10415 Human
  • Unigene: 150749 Human
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    Synonyms:
  • Apoptosis regulator Bcl 2 Antibody
  • Apoptosis regulator Bcl-2 Antibody
  • Apoptosis regulator Bcl2 Antibody
  • AW986256 Antibody
  • B cell CLL/lymphoma 2 Antibody
  • B cell leukemia/lymphoma 2 Antibody
  • Bcl-2 Antibody
  • Bcl2 Antibody
  • BCL2_HUMAN Antibody
  • C430015F12Rik Antibody
  • D630044D05Rik Antibody
  • D830018M01Rik Antibody
  • Leukemia/lymphoma, B-cell, 2 Antibody
  • Oncogene B-cell leukemia 2 Antibody
  • PPP1R50 Antibody
  • Protein phosphatase 1, regulatory subunit 50 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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