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Anti-Bcl-2 Antibody

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产品名称: Anti-Bcl-2 Antibody
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Anti-Bcl-2 Antibody


Anti-Bcl-2 Antibody  的详细介绍
Name: Anti-Bcl-2 Antibody
See all Bcl-2 primary antibodies
Description: Rabbit polyclonal antibody to Bcl-2
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a peptide corresponding to 15 amino acids near the N terminus of human Bcl-2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Ion exchange chromatography purified
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity).
Tissue Specificity: Expressed in a variety of tissues, with highest levels in reproductive tissues. In the ***** brain, expression is localized in mitral cells of the olfactory bulb, granule and pyramidal neurons of hippocampus, pontine nuclei, cerebellar granule neurons, and in ependymal cells. In prenatal brain, expression is higher and localized in the neuroepithelium and in the cortical plate.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors, BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Phosphorylated by MAPK8/JNK1 at Thr-69, Ser-70 and Ser-84, wich stimulates starvation-induced autophagy (By similarity). Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Cellular Location: Mitochondrion outer membrane. Nucleus membrane. Endoplasmic reticulum membrane.
Database Links:
  • Entrez Gene: 596?Human
  • Entrez Gene: 12043?Mouse
  • Entrez Gene: 24224?Rat
  • Omim: 151430?Human
  • SwissProt: P10415?Human
  • SwissProt: P10417?Mouse
  • SwissProt: P49950?Rat
  • Unigene: 150749?Human
  • Unigene: 257460?Mouse
  • Unigene: 9996?Rat
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    Synonyms:
  • Apoptosis regulator Bcl 2 Antibody
  • Apoptosis regulator Bcl-2 Antibody
  • Apoptosis regulator Bcl2 Antibody
  • AW986256 Antibody
  • B cell CLL/lymphoma 2 Antibody
  • B cell leukemia/lymphoma 2 Antibody
  • Bcl-2 Antibody
  • Bcl2 Antibody
  • BCL2_HUMAN Antibody
  • C430015F12Rik Antibody
  • D630044D05Rik Antibody
  • D830018M01Rik Antibody
  • Leukemia/lymphoma, B-cell, 2 Antibody
  • Oncogene B-cell leukemia 2 Antibody
  • PPP1R50 Antibody
  • Protein phosphatase 1, regulatory subunit 50 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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