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Anti-BAX Antibody

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Anti-BAX Antibody


Anti-BAX Antibody  的详细介绍
Name: Anti-BAX Antibody
See all BAX primary antibodies
Description: Mouse monoclonal antibody to BAX.
Applications: WB
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: Recombinant protein of human BAX.
Protein Length: 192
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Tissue Specificity: Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines.
Sequence Similarities: Belongs to the Bcl-2 family.
Cellular Location: Mitochondrion membrane. Cytoplasm.

Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane.
Database Links:
  • Entrez Gene: 581?Human
  • Omim: 600040?Human
  • SwissProt: Q07812?Human
  • Unigene: 624291?Human
    		•
    Synonyms:
  • Apoptosis regulator BAX Antibody
  • Bax Antibody
  • Bax-protein Antibody
  • BAXA Antibody
  • Baxdelta2G9 Antibody
  • Baxdelta2G9omega Antibody
  • Baxdelta2omega Antibody
  • BAX_HUMAN Antibody
  • Bcl-2-like protein 4 Antibody
  • BCL2 associated X protein Antibody
  • BCL2 associated X protein omega Antibody
  • BCL2 associated X protein transcript variant delta2 Antibody
  • Bcl2-L-4 Antibody
  • BCL2L4 Antibody
  • membrane isoform alpha Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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