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Anti-BANF1 Antibody

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产品名称: Anti-BANF1 Antibody
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简单介绍

Anti-BANF1 Antibody


Anti-BANF1 Antibody  的详细介绍
Name: Anti-BANF1 Antibody
See all BANF1 primary antibodies
Description: Rabbit polyclonal antibody to BANF1
Applications: E, WB, IF
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 19 amino acid peptide from near the amino terminus of human BANF1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-s which may promote DNA cross-bridging.
Sequence Similarities: Belongs to the BAF family.
Post-Translational Modification: Ser-4 is the major site of phosphorylation as compared to Thr-2 and Thr-3. Phosphorylation on Thr-2; Thr-3 and Ser-4 disrupts its ability to bind DNA and reduces its ability to bind LEM domain-containing proteins. Non phosphorylated BAF seems to enhance binding between EMD and LMNA. Dephosphorylated by protein phosphatase 2A (PP2A) following interaction with ANKLE2/LEM4 during mitotic exit, leading to mitotic nuclear envelope reassembly.
Cellular Location: Nucleus. Cytoplasm. Chromosome. Nucleus envelope.

Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization whereas the unphosphorylated form locates almost exclusively in the nucleus.
Database Links:
  • Entrez Gene: 8815 Human
  • Entrez Gene: 23825 Mouse
  • Entrez Gene: 114087 Rat
  • Omim: 603811 Human
  • SwissProt: O75531 Human
  • SwissProt: O54962 Mouse
  • SwissProt: Q9R1T1 Rat
  • Unigene: 433759 Human
  • Unigene: 358649 Mouse
  • Unigene: 19921 Rat
    		•
    Synonyms:
  • BAF Antibody
  • BAF_HUMAN Antibody
  • BANF 1 Antibody
  • BANF1 Antibody
  • Barrier to autointegration factor Antibody
  • Barrier to autointegration factor 1 Antibody
  • Barrier-to-autointegration factor Antibody
  • BCRG 1 Antibody
  • BCRG1 Antibody
  • BCRP 1 Antibody
  • BCRP1 Antibody
  • Breakpoint cluster region protein 1 Antibody
  • D14S1460 Antibody
  • MGC111161 Antibody
  • NGPS Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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