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Anti-BAG3 Antibody

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产品名称: Anti-BAG3 Antibody
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简单介绍

Anti-BAG3 Antibody


Anti-BAG3 Antibody  的详细介绍
Name: Anti-BAG3 Antibody
See all BAG3 primary antibodies
Description: Rabbit polyclonal antibody to BAG3
Specificity: The antibody detects endogenous levels of total BAG3 protein.
Applications: WB, IHC
Reactivity: Human
Immunogen: Synthesized peptide derived from internal of human BAG3.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
Involvement in Disease: Myopathy, myofibrillar, 6: A form of myofibrillar myopathy, a group of chronic neuromuscular disorders characterized at ultrastructural level by disintegration of the sarcomeric Z disc and myofibrils, and replacement of the normal myofibrillar markings by small dense granules, or larger hyaline masses, or amorphous material. MFM6 is characterized by early-onset of severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients.

Cardiomyopathy, dilated 1HH: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cellular Location: Nucleus. Cytoplasm.

Colocalizes with BAG3 to the nucleus upon heat stress (PubMed:26159920).
Database Links:
  • Entrez Gene: 9531?Human
  • Omim: 603883?Human
  • SwissProt: O95817?Human
  • Unigene: 523309?Human
    		•
    Synonyms:
  • BAG 3 Antibody
  • BAG family molecular chaperone regulator 3 Antibody
  • BAG-3 Antibody
  • Bag3 Antibody
  • BAG3_HUMAN Antibody
  • Bcl 2 binding protein Antibody
  • Bcl-2-associated athanogene 3 Antibody
  • Bcl-2-binding protein Bis Antibody
  • BCL2 associated athanogene 3 Antibody
  • BCL2 binding athanogene 3 Antibody
  • BIS Antibody
  • CAIR 1 Antibody
  • Docking protein CAIR 1 Antibody
  • Docking protein CAIR-1 Antibody
  • MFM6 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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