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Anti-BAF170 Antibody

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产品名称: Anti-BAF170 Antibody
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Anti-BAF170 Antibody


Anti-BAF170 Antibody  的详细介绍
Name: Anti-BAF170 Antibody
See all BAF170 primary antibodies
Description: Rabbit polyclonal antibody to BAF170
Specificity: BAF170 Polyclonal Antibody detects endogenous levels of BAF170 protein.
Applications: WB, IF, ELISA
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from the Internal region of human BAF170.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1mg / ml
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage: Store at -20˚C / 1 year
Function: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their ***** state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Tissue Specificity: Ubiquitously expressed.
Sequence Similarities: Belongs to the SMARCC family.
Cellular Location: Nucleus.
Database Links:
  • Entrez Gene: 6601 Human
  • Entrez Gene: 68094 Mouse
  • Omim: 601734 Human
  • SwissProt: Q8TAQ2 Human
  • SwissProt: Q6PDG5 Mouse
  • Unigene: 236030 Human
  • Unigene: 632717 Human
  • Unigene: 417338 Mouse
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    Synonyms:
  • BAF 170 Antibody
  • BAF170 Antibody
  • BRG1 associated factor 170 Antibody
  • BRG1-associated factor 170 Antibody
  • Chromatin remodeling complex BAF170 subunit Antibody
  • CRACC 2 Antibody
  • CRACC2 Antibody
  • Mammalian chromatin remodeling complex BRG1 associated factor 170 Antibody
  • Rsc 8 Antibody
  • Rsc8 Antibody
  • SMARCC 2 Antibody
  • Smarcc2 Antibody
  • SMRC2 Antibody
  • SMRC2_HUMAN Antibody
  • SWI/SNF complex 170 kDa subunit Antibody
  • SWI/SNF complex subunit SMARCC2 Antibody
  • SWI/SNF related matrix associated actin dependent regulator of chromatin c2 Antibody
  • SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 Antibody
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 Antibody
  • SWI3 like protein Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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