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Anti-BAD Antibody

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产品名称: Anti-BAD Antibody
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简单介绍

Anti-BAD Antibody


Anti-BAD Antibody  的详细介绍
Name: Anti-BAD Antibody
See all BAD primary antibodies
Description: Rabbit polyclonal antibody to BAD
Applications: E, WB, IHC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a peptide corresponding to 15 amino acids near the C-terminus of human Bad.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Ion exchange chromatography purified
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Tissue Specificity: Expressed in all tissues tested, including brain, liver, spleen and heart. In the brain, restricted to epithelial cells of the choroid plexus. Isoform alpha is the more abundant form.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylated at one or more of Ser-113, Ser-137, Ser-156 and Ser-171 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-137 or Ser-113 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-156, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-137 is the major site of AKT/PKB phosphorylation, Ser-156 the major site of protein kinase A (CAPK) phosphorylation.
Cellular Location: Mitochondrion outer membrane. Cytoplasm.

Colocalizes with HIF3A in the cytoplasm. Upon phosphorylation, locates to the cytoplasm.
Database Links:
  • Entrez Gene: 572?Human
  • Entrez Gene: 12015?Mouse
  • Entrez Gene: 64639?Rat
  • Omim: 603167?Human
  • SwissProt: Q92934?Human
  • SwissProt: Q61337?Mouse
  • SwissProt: O35147?Rat
  • Unigene: 370254?Human
  • Unigene: 4387?Mouse
  • Unigene: 36696?Rat
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    Synonyms:
  • AI325008 Antibody
  • Bad Antibody
  • BAD_HUMAN Antibody
  • BBC 2 Antibody
  • BBC2 Antibody
  • BBC6 Antibody
  • Bcl 2 Antagonist of Cell Death Antibody
  • Bcl 2 Binding Component 6 Antibody
  • BCL X / BCL 2 Binding Protein Antibody
  • BCL X Binding Protein Antibody
  • Bcl XL/Bcl 2 Associated Death Promoter Antibody
  • Bcl-2-binding component 6 Antibody
  • Bcl-2-like protein 8 Antibody
  • Bcl-XL/Bcl-2-associated death promoter Antibody
  • Bcl2 antagonist of cell death Antibody
  • BCL2 antagonist of cell death protein Antibody
  • BCL2 associated agonist of cell death Antibody
  • Bcl2 Associated Death Promoter Antibody
  • BCL2 binding component 6 Antibody
  • BCL2 binding protein Antibody
  • Bcl2 Like 8 Protein Antibody
  • Bcl2-L-8 Antibody
  • BCL2L8 Antibody
  • Proapoptotic BH3 Only Protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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