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Anti-BAD (Ab-136) Antibody

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产品名称: Anti-BAD (Ab-136) Antibody
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Anti-BAD (Ab-136) Antibody


Anti-BAD (Ab-136) Antibody  的详细介绍
Name: Anti-BAD (Ab-136) Antibody
See all BAD primary antibodies
Description: Rabbit polyclonal antibody to BAD (Ab-136)
Specificity: The antibody detects endogenous level of total BAD protein.
Applications: WB, IHC
Dilutions: Western blotting: 1:500~1:1000 Immunohistochemistry: 1:50~1:100
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around aa.134~138 (S-R-S-A-P) derived from Mouse BAD.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration: 1.0mg / ml
Predicted MW: 23kd
Formulation: Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylated on one or more of Ser-112, Ser-136, Ser-155 and Ser-170 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-136 or Ser-112 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-155, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-136 is the major site of AKT/PKB phosphorylation, Ser-155 the major site of protein kinase A (CAPK) phosphorylation.
Cellular Location: Mitochondrion outer membrane. Cytoplasm.

Colocalizes with HIF3A isoform 2 in the cytoplasm (PubMed:21546903). Upon phosphorylation, locates to the cytoplasm.
Database Links:
  • Entrez Gene: 572?Human
  • Entrez Gene: 12015?Mouse
  • Entrez Gene: 64639?Rat
  • Omim: 603167?Human
  • SwissProt: Q92934?Human
  • SwissProt: Q61337?Mouse
  • SwissProt: O35147?Rat
  • Unigene: 370254?Human
  • Unigene: 4387?Mouse
  • Unigene: 36696?Rat
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    Synonyms:
  • AI325008 Antibody
  • Bad Antibody
  • BAD_HUMAN Antibody
  • BBC 2 Antibody
  • BBC2 Antibody
  • BBC6 Antibody
  • Bcl 2 Antagonist of Cell Death Antibody
  • Bcl 2 Binding Component 6 Antibody
  • BCL X / BCL 2 Binding Protein Antibody
  • BCL X Binding Protein Antibody
  • Bcl XL/Bcl 2 Associated Death Promoter Antibody
  • Bcl-2-binding component 6 Antibody
  • Bcl-2-like protein 8 Antibody
  • Bcl-XL/Bcl-2-associated death promoter Antibody
  • Bcl2 antagonist of cell death Antibody
  • BCL2 antagonist of cell death protein Antibody
  • BCL2 associated agonist of cell death Antibody
  • Bcl2 Associated Death Promoter Antibody
  • BCL2 binding component 6 Antibody
  • BCL2 binding protein Antibody
  • Bcl2 Like 8 Protein Antibody
  • Bcl2-L-8 Antibody
  • BCL2L8 Antibody
  • Proapoptotic BH3 Only Protein Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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