产品资料

Anti-BAD (Phospho-Ser91 / 128) Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-BAD (Phospho-Ser91 / 128) Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-BAD (Phospho-Ser91 / 128) Antibody


Anti-BAD (Phospho-Ser91 / 128) Antibody  的详细介绍
Name: Anti-BAD (Phospho-Ser91 / 128) Antibody
See all BAD primary antibodies
Description: Rabbit polyclonal antibody to BAD (Phospho-Ser91 / 128)
Specificity: The antibody detects endogenous levels of BAD only when phosphorylated at serine 91 / serine 128.
Applications: WB, IHC
Dilutions: Western blotting: 1:500~1:1000Immunohistochemistry: 1:50~1:100
Reactivity: Human, Mouse, Rat
Immunogen: Peptide sequence around phosphorylation site of Serine 91 (E-P-S(p)-P-F) derived from Human BAD or Serine 128 (E-P-S(p)-P-F) derived from Mouse BAD.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C / 1 year
Function: Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.
Tissue Specificity: Expressed in a wide variety of tissues.
Sequence Similarities: Belongs to the Bcl-2 family.
Post-Translational Modification: Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation. Phosphorylation at Ser-99 by PKB/AKT1 is almost completely blocked by the apoptotic C-terminus cleavage product of PKN2 generated by caspases-3 activity during apoptosis.
Cellular Location: Mitochondrion outer membrane. Cytoplasm.

Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm.
Database Links:
  • Entrez Gene: 572?Human
  • Entrez Gene: 12015?Mouse
  • Entrez Gene: 64639?Rat
  • Omim: 603167?Human
  • SwissProt: Q92934?Human
  • SwissProt: Q61337?Mouse
  • SwissProt: O35147?Rat
  • Unigene: 370254?Human
  • Unigene: 4387?Mouse
  • Unigene: 36696?Rat
    		•
    Synonyms:
  • AI325008 Antibody
  • Bad Antibody
  • BAD_HUMAN Antibody
  • BBC 2 Antibody
  • BBC2 Antibody
  • BBC6 Antibody
  • Bcl 2 Antagonist of Cell Death Antibody
  • Bcl 2 Binding Component 6 Antibody
  • BCL X / BCL 2 Binding Protein Antibody
  • BCL X Binding Protein Antibody
  • Bcl XL/Bcl 2 Associated Death Promoter Antibody
  • Bcl-2-binding component 6 Antibody
  • Bcl-2-like protein 8 Antibody
  • Bcl-XL/Bcl-2-associated death promoter Antibody
  • Bcl2 antagonist of cell death Antibody
  • BCL2 antagonist of cell death protein Antibody
  • BCL2 associated agonist of cell death Antibody
  • Bcl2 Associated Death Promoter Antibody
  • BCL2 binding component 6 Antibody
  • BCL2 binding protein Antibody
  • Bcl2 Like 8 Protein Antibody
  • Bcl2-L-8 Antibody
  • BCL2L8 Antibody
  • Proapoptotic BH3 Only Protein Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号