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Anti-BACE2 Antibody

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产品名称: Anti-BACE2 Antibody
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简单介绍

Anti-BACE2 Antibody


Anti-BACE2 Antibody  的详细介绍
Name: Anti-BACE2 Antibody
See all BACE2 primary antibodies
Description: Rabbit polyclonal antibody to BACE2
Applications: E, WB, IHC
Reactivity: Human
Immunogen: Raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Tissue Specificity: Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Sequence Similarities: Belongs to the peptidase A1 family.
Post-Translational Modification: Undergoes autoproteolytic cleavage.
Cellular Location: Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
Database Links:
  • Entrez Gene: 25825?Human
  • Omim: 605668?Human
  • SwissProt: Q9Y5Z0?Human
  • Unigene: 529408?Human
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    Synonyms:
  • ALP 56 Antibody
  • ALP56 Antibody
  • Asp 1 Antibody
  • ASP1 Antibody
  • ASP21 Antibody
  • Aspartic Like Protease 56kDa Antibody
  • Aspartic-like protease 56 kDa Antibody
  • Aspartyl protease 1 Antibody
  • BACE 2 Antibody
  • BACE2 Antibody
  • BACE2_HUMAN Antibody
  • Beta Secretase 2 Antibody
  • Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2 Antibody
  • Beta-secretase 2 Antibody
  • Beta-site amyloid precursor protein cleaving enzyme 2 Antibody
  • Beta-site APP cleaving enzyme 2 Antibody
  • Down region aspartic protease Antibody
  • Downs Syndrome Region Aspartic Protease Antibody
  • DRAP Antibody
  • Memapsin 1 Antibody
  • Memapsin-1 Antibody
  • Membrane associated aspartic protease 1 Antibody
  • Membrane-associated aspartic protease 1 Antibody
  • Theta-secretase Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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