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Anti-AZI1 Antibody

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产品名称: Anti-AZI1 Antibody
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Anti-AZI1 Antibody


Anti-AZI1 Antibody  的详细介绍
Name: Anti-AZI1 Antibody
See all AZI1 primary antibodies
Description: Rabbit polyclonal antibody to AZI1
Specificity: The antibody detects endogenous levels of total AZI1 protein.
Applications: WB, IHC
Reactivity: Human, Mouse
Immunogen: Synthesized peptide derived from internal of human AZI1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1.0mg / ml
Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage: Store at -20?C
Function: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).
Sequence Similarities: Belongs to the CEP131 family.
Post-Translational Modification: Ubiquitinated. Undergoes monoubiquitination catalyzed by the E3 ubiquitin-protein ligase MIB1 in proliferating cells, preventing cilia formation. Monoubiquitination by MIB1 is inhibited in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, resulting in cilia formation initiation.
Cellular Location: Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriolar satellite. Cytoplasm > Cytoskeleton > Cilium basal body. Cytoplasmic vesicle > Secretory vesicle > Acrosome.

Colocalized with pericentriolar material protein PCM1 at centriolar satellites. During spermiogenesis, becomes enriched with nephrocystin NPHP1 at the transition zone, a structure at the base of the ciliary axoneme important for regulating traffic into the ciliary compartment. Traffics towards and away from the centrosome/basal body and the transition zone of the ciliary axoneme in a microtubule-dependent manner. Localized at the Golgi-derived acrosome and the centrosome-containing head-tail coupling apparatus (HTCA) (By similarity). Ubiquitinated form is sequestered and colocalized with BBS4, CEP290, PCM1 and PCNT at centriolar satellites in proliferating cells. Colocalized with the pericentriolar material protein PCM1 at centrosome. Traffics towards and away from centriolar satellites and centrosome in a microtubule- and dynein-dependent manner in interphase cells. Displaced from centriolar satellites but still remains associated with the centrosome in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock, in a process that requires p38 MAPK signaling (PubMed:26616734).
Database Links:
  • Entrez Gene: 22994?Human
  • Omim: 613479?Human
  • SwissProt: Q9UPN4?Human
  • Unigene: 514578?Human
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    Synonyms:
  • 5 azacytidine induced 1 Antibody
  • 5-azacytidine-induced protein 1 Antibody
  • AZ1 Antibody
  • Azi Antibody
  • AZI1 Antibody
  • AZI1_HUMAN Antibody
  • Centrosomal protein 131 kDa Antibody
  • Centrosomal protein of 131 kDa Antibody
  • Cep131 Antibody
  • KIAA1118 Antibody
  • OTTMUSP00000004498 Antibody
  • Pre-acrosome localization protein 1 Antibody
  • RP23 37J21.1 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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