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Anti-AXIN2 Antibody

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产品名称: Anti-AXIN2 Antibody
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Anti-AXIN2 Antibody


Anti-AXIN2 Antibody  的详细介绍
Name: Anti-AXIN2 Antibody
See all AXIN2 primary antibodies
Description: Rabbit polyclonal antibody to AXIN2.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:20 - 1:50.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human AXIN2.
Protein Length: 843
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).
Tissue Specificity: Expressed in brain and lymphoblast.
Involvement in Disease: Colorectal cancer: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

Oligodontia-colorectal cancer syndrome: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
Post-Translational Modification: Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
Cellular Location: Cytoplasm.
Database Links:
  • Entrez Gene: 8313?Human
  • Entrez Gene: 12006?Mouse
  • Entrez Gene: 29134?Rat
  • Omim: 604025?Human
  • SwissProt: Q9Y2T1?Human
  • SwissProt: O88566?Mouse
  • SwissProt: O70240?Rat
  • Unigene: 156527?Human
  • Unigene: 71710?Mouse
  • Unigene: 162212?Rat
    		•
    Synonyms:
  • Axil Antibody
  • Axin 2 Antibody
  • Axin like protein Antibody
  • Axin-2 Antibody
  • Axin-like protein Antibody
  • Axin2 Antibody
  • AXIN2_HUMAN Antibody
  • Axis inhibition protein 2 Antibody
  • Conductin Antibody
  • DKFZp781B0869 Antibody
  • MGC10366 Antibody
  • MGC126582 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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