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Anti-AXIN1 Antibody

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产品名称: Anti-AXIN1 Antibody
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Anti-AXIN1 Antibody


Anti-AXIN1 Antibody  的详细介绍
Name: Anti-AXIN1 Antibody
See all AXIN1 primary antibodies
Description: Rabbit polyclonal antibody to AXIN1
Applications: E, WB, ICC
Reactivity: Human, Mouse, Rat
Immunogen: Raised against a 14 amino acid peptide near the carboxy terminus of human AXIN1.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Affinity chromatography purified via peptide column
Formulation: Supplied in PBS containing 0.02% sodium azide.
Storage: Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Function: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (By similarity). Also facilitates the phosphorylation of APC by GSK3B (By similarity). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (By similarity). Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity).
Tissue Specificity: Highly expressed in testis, thymus and lung. Less expression in cerebrum, cerebellum, heart, kidney, skeletal muscle, spleen and liver.
Post-Translational Modification: Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1. Also phosphorylated by CDK2 which regulates interaction with CTNBB1 (By similarity).
Cellular Location: Cytoplasm. Nucleus. Cell membrane. Membrane.

On UV irradiation, translocates to the nucleus and colocalizes with DAAX (By similarity). MACF1 is required for its translocation to cell membrane (By similarity).
Database Links:
  • Entrez Gene: 8312 Human
  • Entrez Gene: 12005 Mouse
  • Entrez Gene: 79257 Rat
  • Omim: 603816 Human
  • SwissProt: O15169 Human
  • SwissProt: O35625 Mouse
  • SwissProt: O70239 Rat
  • Unigene: 592082 Human
  • Unigene: 23684 Mouse
  • Unigene: 31781 Rat
    		•
    Synonyms:
  • AI316800 Antibody
  • AXIN Antibody
  • Axin 1 Antibody
  • Axin-1 Antibody
  • Axin1 Antibody
  • AXIN1_HUMAN Antibody
  • Axis inhibition protein 1 Antibody
  • Axis Inhibitor 1 Antibody
  • Fu Antibody
  • fused Antibody
  • Fused, mouse, homolog of Antibody
  • hAxin Antibody
  • Kb Antibody
  • Ki Antibody
  • kinky Antibody
  • knobbly Antibody
  • MGC132911 Antibody
  • MGC52315 Antibody
  • PPP1R49 Antibody
  • Protein Fused Antibody
  • Protein phosphatase 1 regulatory subunit 49 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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