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Anti-AXIN1 Antibody

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Anti-AXIN1 Antibody


Anti-AXIN1 Antibody  的详细介绍
Name: Anti-AXIN1 Antibody
See all AXIN1 primary antibodies
Description: Rabbit polyclonal antibody to AXIN1
Specificity: The antibody detects endogenous levels of total AXIN1 protein.
Applications: IHC
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide of human AXIN1
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Purification: Antigen affinity purification.
Concentration: 2mg / ml
Formulation: Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage: Store at -20?C
Function: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Tissue Specificity: Ubiquitously expressed.
Involvement in Disease: Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Caudal duplication anomaly: A condition characterized by the occurrence of duplications of different organs in the caudal region.
Post-Translational Modification: Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1.
Cellular Location: Cytoplasm. Nucleus. Membrane. Cell membrane.

MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).
Database Links:
  • Entrez Gene: 8312?Human
  • Entrez Gene: 12005?Mouse
  • Entrez Gene: 79257?Rat
  • Omim: 603816?Human
  • SwissProt: O15169?Human
  • SwissProt: O35625?Mouse
  • SwissProt: O70239?Rat
  • Unigene: 592082?Human
  • Unigene: 23684?Mouse
  • Unigene: 31781?Rat
    		•
    Synonyms:
  • AI316800 Antibody
  • AXIN Antibody
  • Axin 1 Antibody
  • Axin-1 Antibody
  • Axin1 Antibody
  • AXIN1_HUMAN Antibody
  • Axis inhibition protein 1 Antibody
  • Axis Inhibitor 1 Antibody
  • Fu Antibody
  • fused Antibody
  • Fused, mouse, homolog of Antibody
  • hAxin Antibody
  • Kb Antibody
  • Ki Antibody
  • kinky Antibody
  • knobbly Antibody
  • MGC132911 Antibody
  • MGC52315 Antibody
  • PPP1R49 Antibody
  • Protein Fused Antibody
  • Protein phosphatase 1 regulatory subunit 49 Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
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