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Anti-AURKC Antibody

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产品名称: Anti-AURKC Antibody
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简单介绍

Anti-AURKC Antibody


Anti-AURKC Antibody  的详细介绍
Name: Anti-AURKC Antibody
See all Aurora C primary antibodies
Description: Goat polyclonal antibody to AURKC.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Synthetic peptide corresponding to Human AURKC (N terminal).
Sequence: PRAVVQLGKAQP-C
Host: Goat
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 100 µg at 0.5 mg/ml.
Product Form: Liquid
Formulation: Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Tissue Specificity: Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Involvement in Disease: Spermatogenic failure 5: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome.
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Cellular Location: Nucleus. Chromosome. Chromosome > Centromere. Cytoplasm > Cytoskeleton > Spindle.

Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Database Links:
  • Entrez Gene: 6795 Human
  • Omim: 603495 Human
  • SwissProt: Q9UQB9 Human
  • Unigene: 98338 Human
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    Synonyms:
  • AURKC Antibody
  • AIE 2 Antibody
  • Aie1 Antibody
  • AIE2 Antibody
  • AIK 3 Antibody
  • AIK3 Antibody
  • ARK 3 Antibody
  • ARK-3 Antibody
  • ARK3 Antibody
  • Aur C Antibody
  • AurC Antibody
  • Aurkc Antibody
  • AURKC_HUMAN Antibody
  • aurora 3 Antibody
  • Aurora C Antibody
  • Aurora kinase C Antibody
  • aurora related kinase 3 Antibody
  • Aurora-related kinase 3 Antibody
  • Aurora/Ipl1 related kinase 3 Antibody
  • Aurora/Ipl1-related kinase 3 Antibody
  • Aurora/Ipl1/Eg2 protein 2 Antibody
  • EC 2.7.11.1 Antibody
  • IPL-1/STK13/Aurora C Antibody
  • Serine threonine protein kinase 13 Antibody
  • serine/threonine kinase 13 (aurora/IPL1 like) Antibody
  • serine/threonine protein kinase aurora C Antibody
  • Serine/threonine-protein kinase 13 Antibody
  • Serine/threonine-protein kinase aurora-C Antibody
  • SPGF5 Antibody
  • STK13 Antibody
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    Information: Target information shown above is from the UniProt Consortium.
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