产品资料

Anti-ATP7B Antibody

如果您对该产品感兴趣的话,可以
产品名称: Anti-ATP7B Antibody
产品型号:
产品展商: 其它品牌
产品文档: 无相关文档

简单介绍

Anti-ATP7B Antibody


Anti-ATP7B Antibody  的详细介绍
Name: Anti-ATP7B Antibody
See all ATP7B primary antibodies
Description: Rabbit polyclonal antibody to ATP7B.
Applications: WB, IHC, IF
Dilutions: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein of human ATP7B.
Protein Length: 1465
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
Tissue Specificity: Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
Involvement in Disease: Wilson disease: An autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis.
Sequence Similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
Post-Translational Modification: Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
Cellular Location: Golgi apparatus > trans-Golgi network membrane. Late endosome.

Predominantly found in the trans-Golgi network (TGN). Localized in the trans-Golgi network under low copper conditions, redistributes to cytoplasmic vesicles when cells are exposed to elevated copper levels, and then recycles back to the trans-Golgi network when copper is removed (PubMed:10942420). Not redistributed to the plasma membrane in response to elevated copper levels.
Database Links:
  • Entrez Gene: 540?Human
  • Entrez Gene: 11979?Mouse
  • Entrez Gene: 24218?Rat
  • Omim: 606882?Human
  • SwissProt: P35670?Human
  • SwissProt: Q64446?Mouse
  • SwissProt: Q64535?Rat
  • Unigene: 492280?Human
    		•
    Synonyms:
  • ATP7b Antibody
  • ATP7B_HUMAN Antibody
  • ATPase, Cu(2+) transporting, beta polypeptide Antibody
  • ATPase, Cu++ transporting, beta polypeptide Antibody
  • Copper pump 2 Antibody
  • Copper transporting ATPase 2 Antibody
  • PWD Antibody
  • Toxic milk Antibody
  • tx Antibody
  • WC1 Antibody
  • WD Antibody
  • Wilson disease associated protein Antibody
  • Wilson disease-associated protein Antibody
  • WND Antibody
  • WND/140 kDa Antibody
    		•
    Information: Target information shown above is from the UniProt Consortium.
    产品留言
    标题
    联系人
    联系电话
    内容
    验证码
    点击换一张
    注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
    2.如有必要,请您留下您的详细联系方式!

    沪公网安备 31011202007337号